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免疫赦免是眼免疫系统的一个重要特征 ,而前房相关性免疫偏离是眼免疫赦免的中心部分。本文总结近年来关于两者的研究成果 ,较全面地介绍两者形成的生理基础及免疫机制 ,尤其是一些细胞因子如TGF β的重要作用 ,进一步阐明了眼免疫赦免及前房相关性免疫偏离的本质。研究眼免疫赦免及前房相关性免疫偏离具有重要的临床意义 ,目前已应用于自身免疫性葡萄膜炎的治疗、高危角膜移植、视网膜色素上皮移植排异机制的研究及防治。
Immuno-pardon is an important feature of the eye’s immune system, while anterior chamber-related immunodeficiency is a central part of ophthalmic immunization. This article summarizes recent research results on both, and more comprehensively introduces the physiological basis and immune mechanisms formed by the two, especially the important role of some cytokines such as TGF β, and further clarifies the relationship between ophthalmic immune pardon and anterior chamber-related immune deviation The essence. It is of great clinical significance to study eye immunization and anterior chamber-related immune deviation. It has been used in the treatment of autoimmune uveitis, research on the mechanism of rejection of high-risk corneal transplantation and retinal pigment epithelium transplantation and prevention and treatment.