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目的:探讨重组人碱性成纤维细胞生长因子(rh-bFGF)对经皮冠状动脉腔内成形术后再狭窄的预防效果。方法:用2F球囊导管造成大鼠左颈总动脉内皮损伤。治疗组每天im rh-bFGF 10 kU/kg。分别于术后7天和14天,每组各处死大鼠10只,取左颈总动脉进行[~3H]胸腺嘧啶掺入测定和病理形态学检查。结果:在第7天和第14天时,与模型对照组相比,rh-bFGF治疗组颈总动脉平均新生内膜厚度明显变薄;平均中膜面积缩小;平滑肌细胞和弹力板层数减少;胶原含量及[~3H]胸腺嘧啶掺入量也比模型对照组明显降低。结论:适当应用rh-bFGF有抑制气囊损伤后动脉新生内膜增厚,降低再狭窄发生的作用。
Objective: To investigate the preventive effect of recombinant human basic fibroblast growth factor (rh-bFGF) on restenosis after percutaneous transluminal coronary angioplasty. Methods: The left common carotid artery endothelial injury was induced by 2F balloon catheter in rats. The treatment group daily im rh-bFGF 10 kU / kg. At 7 and 14 days after operation, 10 rats in each group were sacrificed and the left common carotid artery was taken for 3H-thymidine incorporation and histopathological examination. Results: Compared with the model control group, the mean neointimal thickness of the common carotid arteries in the rh-bFGF treatment group was significantly thinner on the 7th and 14th days; the mean medial membrane area was reduced; the number of smooth muscle cells and elastic laminae was decreased; Collagen content and [~ 3H] thymidine incorporation were also significantly lower than the model control group. Conclusion: Appropriate rh-bFGF can inhibit the neointimal thickening and reduce the restenosis after balloon injury.