慢性肾功能衰竭是各种原因导致的慢性进行性肾损害,致使肾脏不能维持基本功能而出现一系列临床症状的综合征。一般认为,肾实质损害与肾进行性纤维化有关,而致肾纤维化的机制尚未完全清楚。IV型胶原(CL-IV)是正常肾小球系膜基质和毛细血管基质的重要成份,而血清IV型胶原与慢性肾 Chronic renal failure is caused by a variety of chronic progressive renal damage, resulting in the basic function of the kidneys can not maintain a series of symptoms of clinical syndrome. It is generally believed that renal parenchymal damage and renal progressive fibrosis, and the mechanism of renal fibrosis has not yet fully understood. Type IV collagen (CL-IV) is an important component of normal glomerular mesangial matrix and capillary matrix, and serum type IV collagen and chronic kidney