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目的 研究可溶性Fas(sFas)和可溶性Fas配体(sFasL)在乙型肝炎发病中的意义。方法 用ELISA双抗体夹心法检测39例各种类型乙型肝炎患者血清sFas和sFasL含量及其与病变的关系，并以8例健康献血员血清作对照。结果 慢性肝炎（中～重型）血清中sFas含量较高，与其它各组比较有显著性差异（Ｐ<0.01）；重型肝炎血清中sFasL含量较高，与其它各组比较亦有显著性差异（Ｐ<0.01）。血清中sFasL含量较高的患者病情较重、病死率较高；相反，血清sFas含量较高的患者病情活动一般亦较明显，但绝大部分预后较好。结论 血清sFas和sFasL含量与乙型肝炎病情密切相关，二者可作为判断病情和估计预后的重要指标，它们在肝细胞凋亡引致肝损害的发生中起重要作用。
Objective To investigate the significance of soluble Fas (sFas) and soluble Fas ligand (sFasL) in the pathogenesis of hepatitis B (HBV). Methods Serum levels of sFas and sFasL in 39 patients with various types of hepatitis B were detected by ELISA sandwich ELISA. The relationship between the levels of sFas and sFasL and the pathological changes was analyzed. Eight healthy blood donors were used as controls. Results Serum levels of sFas were higher in chronic hepatitis (moderate to severe) than those in other groups (P <0.01). Serum levels of sFasL in severe hepatitis were significantly higher than those in other groups P <0.01). Serum sFasL higher levels of patients with severe disease, higher mortality; the contrary, the higher serum sFas levels in patients with disease activity is generally more obvious, but most of the prognosis is better. Conclusion Serum sFas and sFasL levels are closely related to the severity of hepatitis B. Both of them may be used as an important index to judge the prognosis and prognosis. They play an important role in the pathogenesis of hepatic injury induced by hepatocyte apoptosis.