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本文观察了氚的β射线诱发雌性大鼠乳腺肿瘤的相对生物效应(RBE)。参照辐射源是200～kVpX射线。实验动物为Sprague-Deweley雌性大鼠,平均体重180克,45～50天日龄。每组120～130只。慢性(10天)X射线照射分4组,总剂量分别为0.29、0.57、1.1和2.0Gy。急性(1h)X射线照射分2组,总剂量为0.75和1.78Gy。氚的β射线照射分4组。氚的标准浓度分别为45.89、178和370MBq/100g体重,每只大鼠第一次分别腹腔注射全量(0.5～1.0ml容积),然后每2天注射半量,反复注射4次,(生物半衰期约为2天)。根据标准换算系数计算,1μCi氚平均分布在1克密度为1的物质中,剂量率为1.214×10~(-4)Gy/h。组织中氚的总浓度则等于有机物质中测得的氚浓度加上尿氚浓度的
This article examines the relative bioavailability (RBE) of tritium-induced beta-rays in female rat breast tumors. Reference radiation source is 200 ~ kVpX ray. The experimental animals were Sprague-Deweley female rats with an average body weight of 180 grams and 45-50 days of age. Each group of 120 to 130. Chronic (10 days) X-ray irradiation was divided into 4 groups at a total dose of 0.29, 0.57, 1.1 and 2.0 Gy, respectively. Acute (1h) X-ray irradiation was divided into two groups at a total dose of 0.75 and 1.78 Gy. Tritium β-ray irradiation divided into 4 groups. The standard concentrations of tritium were 45.89,178 and 370MBq / 100g body weight respectively. Each rat was injected intraperitoneally with the full amount (0.5-1.0 ml volume) for the first time, then half every two days and repeated injection for 4 times For 2 days). Calculated according to the standard conversion factor, 1μCi tritium is evenly distributed in 1g of material with a density of 1 at a dose rate of 1.214 × 10 -4 Gy / h. The total concentration of tritium in the tissue then equals the tritium concentration measured in the organic material plus the urinary tritium concentration