第五讲临床试验几种常用的设计方法在临床试验中,还是广泛应用单因素的设计方法。多因素设计则多见于临床实验室的研究。下面着重介绍临床试验中常用的几种设计方法。一、自身对照设计自身对照试验是在同一受试者身上进行。此种试验的设计有三种形式:(1)对每个观察单位进行两次观察,第一次观察不给处理,第二次观察给予处理,两次结果的差值作为实验效应;(2)第一次给予处理 A,第二次给予处理 B,也以两次结果的差值作为 Lecture 5: Several commonly used design methods for clinical trials In clinical trials, single-factor design methods are widely used. Multi-factorial design is more common in clinical laboratory research. The following focuses on several design methods commonly used in clinical trials. I. Self-control design Self-control experiments were performed on the same subject. The design of this type of test has three forms: (1) Two observations are performed for each observation unit, the first observation is not treated, and the second observation is given for treatment. The difference between the two results is used as the experimental effect; (2) A treatment is given for the first time, and treatment B is given for the second time. The difference between the two results is also taken as