论文部分内容阅读
本品为卫矛科雷公藤属植物雷公藤 Trip-terygium wilfordii Hook.f.的去皮根的提取物经加工制成的糖衣片剂,除去糖衣后呈棕褐色,味苦。药理和临床研究证实,本品含有抗炎及免疫抑制的活性组分,属非甾体免疫抑制抗炎剂,已由中国医学科学院皮肤病研究所,南京药学院,上海第一医学院附属华山、中山医院与上海中药二厂研究成功,于1982年先后在南京、金华通过鉴定。药理作用:抗炎作用。本品对大鼠蛋清性关节炎有一定的预防作用,其作用与药物剂量及用药时间有关。本品10mg/kg 对正常大鼠甲醛性足蹠肿胀有抑制作用,并可持续24小时以上。它对原发性佐剂关节炎有直接抗炎作用,其抗炎机制与肾上腺皮质激素不同,可能与本
This product is a sugar-coated tablet made from the peeled root extract of Tripterygium wilfordii Hook.f. of Tripterygium wilfordii. It is brownish and bitter after removing sugar coating. Pharmacological and clinical studies have confirmed that this product contains anti-inflammatory and immunosuppressive active ingredients and is a non-steroidal immunosuppressive anti-inflammatory agent. It has been developed by the Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing University of Pharmacy, and Huashan, the Shanghai First Medical College. The successful research of Zhongshan Hospital and Shanghai No. 2 Traditional Chinese Medicine Factory was passed in 1982 in Nanjing and Jinhua. Pharmacological effects: anti-inflammatory effect. This product has a certain preventive effect on rat egg white arthritis, and its role is related to the dose and time of medication. This product 10mg/kg inhibition of formaldehyde in normal rat paw swelling, and sustainable for more than 24 hours. It has a direct anti-inflammatory effect on primary adjuvant arthritis. Its anti-inflammatory mechanism is different from that of adrenocorticotropic hormone, and may be related to