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癌症已成为人类最重要的死亡原因之一。DNA修复在维持细胞遗传稳定性和细胞稳态等方面起着重要的作用。DNA修复失常与癌症发生有关,并且是癌症治疗的重要靶点。自上世纪70年代起,DNA修复一直是生物化学、遗传学、毒理学和癌症研究的热门课题。1994年“Sci- ence”杂志曾评选明星分子作为封面,此后有关的研究报告迅速增加,方法和概念不断改进,更新和扩展,取得了大量新的成果。美国Taxas大学魏庆义教授(Qingyi Wei),李磊(Lei Li)和陈正已(David J Chen)主编了《DNA Repair,Genetic Instability and Cancer》(《DNA修复,遗传不稳定性和癌症》)一书(World Scientific Publishing Co.2007.P.353),对此进行了全面论述和总结。
Cancer has become one of the most important causes of death in humans. DNA repair plays an important role in maintaining cellular genetic stability and cell homeostasis. DNA repair disorders associated with cancer, and cancer treatment is an important target. Since the 1970s, DNA repair has been a hot topic in biochemistry, genetics, toxicology and cancer research. In 1994, when “Scientology” magazine named celebrities as the cover page, the related research reports increased rapidly thereafter. Methods and concepts were continuously improved, updated and expanded, and a great deal of new achievements were made. DNA Repair, Genetic Instability and Cancer, edited by Qingyi Wei, Lei Li and David J Chen of the Taxas University in the United States (World Scientific Publishing Co. 2007, p. 353), a comprehensive discussion and summary.