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目的探讨自体骨髓干细胞移植与通脉化瘀汤合用治疗糖尿病足的疗效。方法选择45例因慢性下肢缺血引起糖尿病足患者,分为常规治疗组(A组)15例,共30条患肢,自体骨髓干细胞移植治疗组(B组)15例,共28条患肢,自体骨髓干细胞移植与通脉化瘀汤合用治疗组(C组)15例,共29条患肢。治疗12周,观察各项指标,对疗效进行评估。结果A组治疗前后各项指标比较差异无统计学意义(P>0.05)。B组及C组治疗后较治疗前肢体疼痛、冷感、间歇跛行、皮肤温度、踝臂指数均有改善,差异有统计学意义(P<0.05)。C组治疗后在缓解肢体疼痛、冷感、间歇跛行、皮肤温度方面与B组治疗后比较更有效,差异有统计学意义(P<0.05)。结论自体骨髓干细胞移植技术治疗因慢性下肢缺血引起糖尿病足是有效的方法,与中药通脉化瘀汤合用可以提高自体骨髓干细胞移植技术的疗效。
Objective To investigate the efficacy of autologous bone marrow stem cell transplantation combined with Tongmai Huayu Decoction in the treatment of diabetic foot. Methods Fifty-five diabetic patients with chronic leg ischemia were selected and divided into 15 groups (A group), 15 patients (B group), and 30 patients with BMSCs (Group B) , 15 cases of autologous bone marrow stem cell transplantation combined with Tongmai Huayu Decoction group (C group), a total of 29 limbs. After 12 weeks of treatment, the indexes were observed and the efficacy was evaluated. Results There was no significant difference in each index between before and after treatment in group A (P> 0.05). The pain, cold sensation, intermittent claudication, skin temperature and ankle-brachial index in both groups B and C were significantly improved after treatment (P <0.05). After treatment, C group was more effective in relieving limb pain, cold sensation, intermittent claudication and skin temperature compared with B group after treatment, the difference was statistically significant (P <0.05). Conclusion Autologous bone marrow stem cell transplantation for the treatment of diabetic foot due to chronic lower limb ischemia is an effective method. Combined with traditional Chinese medicine Tongmai Huayu Decoction can improve the efficacy of autologous bone marrow stem cell transplantation.