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Rho亚家族属于ras超基因家族,Rho蛋白最重要的作用是调节肌动蛋白骨架系统,在细胞生长、黏附变形和游走调控中起开关作用。Rho亚家族与乳腺癌的侵袭、转移密切相关,以Rho/ROCK为靶点的治疗有望成为新的抗乳腺癌转移的方法。现就Rho亚家族与乳腺癌关系的研究进展予以综述。
The Rho subfamily belongs to the ras supergene family. The most important role of Rho proteins is to regulate the actin scaffolding system and to act as a switch in the regulation of cell growth, adhesion deformation and migration. The Rho subfamily is closely related to the invasion and metastasis of breast cancer, and the treatment targeting Rho / ROCK is expected to become a new method of breast cancer metastasis. The research progress on the relationship between Rho subfamily and breast cancer is reviewed.