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目的探讨吸烟与2型糖尿病病足早期危险性的关系。方法将104例2型糖尿病患者(T_2DM)根据有否吸烟分为吸烟组(45例)和非吸烟组(59例),检测空腹血糖(FBG)、餐后2h血糖(PBG2h)、糖化血红蛋白(HbA_1c)、血胆固醇(TC)、甘油三脂(TG)、高密度和低密度脂蛋白胆固醇(HDL-C、LDL-C)、肾功能(BUN、Cr)、C反应蛋白(CRP)、踝动脉-肱动脉血压比值(ABI)等指标,进行组问对比分析。结果吸烟组与非吸烟组比较,CRP增高[(8．45±13．15)vs(3．56±4．58),P＜0．01],HDL-C降低[(1．04±0．26)vs (1．22±0．45),P＜0．05]；吸烟组糖尿病病足早期发生率显著高于非吸烟组(P＜0．05)。结论吸烟是糖尿病病足早期重要的独立危险因素。
Objective To investigate the relationship between smoking and type 2 diabetic foot disease early risk. Methods T 2DM patients were divided into smoking group (45 cases) and non - smoking group (59 cases) according to the presence or absence of smoking, and the levels of fasting blood glucose (FBG), postprandial 2h blood glucose (PBG2h), glycosylated hemoglobin HbA_1c, TC, TG, HDL-C, LDL-C, BUN, CR, Arterial - brachial artery blood pressure ratio (ABI) and other indicators, the group asked comparative analysis. Results Compared with non-smoker group, CRP increased (8.45 ± 13.15 vs 3.56 ± 4.58, P <0.01), and HDL-C decreased (1.04 ± 0 .26) vs (1.22 ± 0.45), P <0.05]. The incidence of diabetic foot disease in smoking group was significantly higher than that in non-smoking group (P <0.05). Conclusion Smoking is an important independent risk factor for early diabetic foot disease.