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目的:分析急性白血病(AL)外周血内免疫细胞水平变化的临床价值。方法:选取120例AL患者和50例健康体检者作为研究对象,分别纳入初诊组(107例)、移植组(13例)、对照组(50例),比较各组外周血内免疫细胞水平的差异。结果:初诊组107例患者中,完全缓解(CR)63例(58.88%),部分缓解10例(9.35%),未缓解22例(20.56%),其余12例(11.21%)死亡或放弃治疗。初诊组患者入组时、CR患者治疗后1个月、未缓解者治疗后Treg细胞显著高于对照组,NK细胞显著低于对照组(P<0.05);CR患者治疗后3个月、移植组患者移植成功后Treg细胞、NK细胞与对照组比较,差异无统计学意义(P>0.05)。初诊组患者入组时、未缓解者治疗后、移植组患者移植成功后CD4~+、CD4~+/CD8~+水平显著低于对照组(P<0.05);CR患者治疗后1个月及治疗后3个月T淋巴细胞亚群与对照组比较,差异无统计学意义(P>0.05)。结论:长期监测AL患者外周血Treg细胞、NK细胞及T淋巴细胞亚群水平有助于明确治疗效果、预测预后质量。
Objective: To analyze the clinical value of the change of immune cells in peripheral blood of patients with acute leukemia (AL). Methods: A total of 120 patients with AL and 50 healthy subjects were enrolled in this study. They were enrolled in the newly diagnosed group (107 cases), the transplantation group (13 cases) and the control group (50 cases) respectively. The levels of peripheral immune cells difference. Results: Of the 107 newly diagnosed patients, 63 (58.88%) had complete remission (CR), 10 had partial remission (9.35%), 22 had failed remission (20.56%) and the remaining 12 patients (11.21% . Treg cells in untreated patients were significantly higher than those in control group and NK cells were significantly lower than those in control group (P <0.05); CR patients were transplanted 3 months after treatment There was no significant difference in Treg cells and NK cells between the two groups after transplantation (P> 0.05). In the newly diagnosed group, the levels of CD4 ~ + and CD4 ~ + / CD8 ~ + were significantly lower than those of the control group after transplantation (P <0.05) There was no significant difference in T-lymphocyte subsets between the three months after treatment and the control group (P> 0.05). CONCLUSION: Long-term monitoring of the levels of Treg cells, NK cells and T lymphocyte subsets in peripheral blood of patients with AL helps to clarify the therapeutic effect and predict the quality of prognosis.