论文部分内容阅读
目的探讨哈萨克族老年慢性阻塞性肺疾病(COPD)患者T淋巴细胞亚群CD3~+、CD4~+、CD8~+的表达水平及意义。方法选择2013年7月至2015年6月在奎屯市医院住院诊治的COPD患者30例作为研究对象,选择同期20名健康体检者作为对照组,检测T淋巴细胞亚群表达水平。结果 COPD患者CD3~+、CD4~+和CD4~+/CD8~+低于对照组,而COPD患者CD8~+表达水平高于对照组。结论哈萨克族老年COPD患者机体存在细胞免疫功能紊乱现象,T淋巴细胞亚群表达水平异常在COPD的发生发展中起重要作用。
Objective To investigate the expression and significance of CD3 +, CD4 +, CD8 + in T lymphocyte subsets in Kazak elderly patients with chronic obstructive pulmonary disease (COPD). Methods Totally 30 COPD patients hospitalized in Kuitun City Hospital from July 2013 to June 2015 were selected as the research objects. Twenty healthy controls were selected as the control group to detect the expression of T lymphocyte subsets. Results The levels of CD3 ~ +, CD4 ~ + and CD4 ~ + / CD8 ~ + in patients with COPD were lower than those in the control group, while those in COPD patients were higher than those in the control group. Conclusion The elderly COPD patients have cellular immune dysfunction and the abnormal expression of T lymphocyte subsets plays an important role in the pathogenesis of COPD.