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在什么范围内用药对治疗适合?在什么范围内用药不良反应发生率最低?本文提出循证医学研究的新方法——黄金区域法,以解决这两个问题。考察量效关系,以黄金区域为中段,把经验范围分成三段是研究设计的关键。超大样本循证调查显示抗菌素使用剂量与产生不良反应存在U形规律,剂量在黄金区域内处于U形底部。用黄金区域法规定用药剂量是当前解决上述两个盲区难题的特殊突破口。
In what extent is the medication suitable for treatment and in what extent is the lowest incidence of adverse drug reactions? This article presents a new method of evidence-based medical research - the golden zone method to solve both problems. To study the relationship between the quantity and the effect, taking the gold area as the middle section and dividing the experience range into three sections is the key to the research design. Evidence from a large sample of evidence-based surveys showed that there was a U-shaped pattern of dose and adverse reactions in antibiotics, with the dose at the bottom of the U shape in the golden zone. The Golden Zone Law stipulates that the dosage should be a special breakthrough to solve the above two dead zones.