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目的:研究亚硒酸钠与丹参注射液联合应用的抗血栓作用,寻求两药配伍使用的最佳剂量。方法:采用L9(34)的正交设计方法,考察药物对下腔静脉结扎法形成血栓的影响。结果:亚硒酸钠与丹参注射液最佳剂量组合为亚硒酸钠高剂量与丹参注射液中剂量。结论:亚硒酸钠高剂量(1×10-3 g/kg)与丹参注射液中剂量(3.75g/kg)伍用抗血栓效果最佳。
Objective: To study the antithrombotic effect of sodium selenite combined with Salvia miltiorrhiza injections, and to find out the optimal dosage for compatibility of two drugs. Methods: The orthogonal design of L9 (34) was used to investigate the effect of drugs on thrombus formation by ligation of inferior vena cava. Results: The best dose combination of sodium selenite and Salvia miltiorrhiza injection was the high dose of sodium selenite and the dose of Salvia miltiorrhiza injection. Conclusion: The highest antithrombotic effect of sodium selenite at high dose (1 × 10-3 g / kg) and Salvia miltiorrhiza injection (3.75g / kg) is best.