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目的 :探析乙型肝炎病毒母婴传播及乙肝疫苗接种的预防效果。方法 :回顾分析230例HBs Ag阳性孕妇及其患儿,分析孕妇HBIG使用情况与婴儿免疫方式,并对乙肝高危儿乙肝标志物进行检测。结果 :230例HBs Ag阳性孕妇中,43例使用过HBIG;187例孕妇未使用过HBIG,注射组有2例为HBs Ag阳性,未注射组6例为HBs Ag阳性,两组患者HBs Ag阳性率比较,差异不明显,P>0.05。跟踪随访过程中,共有36例婴儿单纯进行了乙肝疫苗接种,194例婴儿采用HBIG与乙肝疫苗联合免疫,其中单纯组共有3例为HBs Ag阳性,联合组共有5例为HBs Ag阳性,两组比较单纯组HBs Ag阳性率明显高于联合组,差异明显,P<0.05。结论 :为了阻断HBs Ag阳性孕妇及婴儿乙肝病毒的母婴传播,孕妇使用HBIG无助于HBV母婴传播的降低,对婴儿注射HBIG、接种乙肝疫苗接种,有利于婴儿HBV感染率降低。
Objective: To explore the preventive effect of mother-to-child transmission of hepatitis B virus and hepatitis B vaccination. Methods: A retrospective analysis of 230 cases of HBsAg-positive pregnant women and their children, analysis of HBIG pregnant women use and infant immunization methods, and hepatitis B high-risk hepatitis B markers were detected. Results: Of the 230 HBsAg-positive pregnant women, HBIG-Ag was used in 43 cases, HBIG was not used in 187 pregnant women, HBs Ag was positive in 2 cases in injected group, HBs Ag was positive in 6 cases in non-injected group, HBs Ag was positive in both groups Rate comparison, the difference is not obvious, P> 0.05. During follow-up, 36 infants were vaccinated with hepatitis B vaccine alone. A total of 194 infants were immunized with HBIG and hepatitis B vaccine. In the simple group, 3 cases were positive for HBsAg, 5 cases in the combined group were positive for HBsAg, Compared with the simple group HBsAg positive rate was significantly higher than the combined group, the difference was significant, P <0.05. Conclusion: In order to prevent mother-to-child transmission of hepatitis B virus (HBsAg) -positive and infantile hepatitis B virus (HBV) in pregnant women, it is not helpful to reduce the mother-to-child transmission of HBV. HBIG injection and hepatitis B vaccination are beneficial to the reduction of HBV infection in infants.