Summary: To study the expression of peroxisome proliferator-activated receptor-γ(PPAR-γ) in lungcancer cells, and to testify if the PPAR-γ agonists can inhibit human lung cancer cell growth throughinduction of apoptosis, PPAR-γ was detected in two lung cancer cell lines by RT-PCR and immuno-histochemistry, the inhibition of human lung cancer cell growth was investigated by MTT and cellcounts, and the apoptosis was assessed by TUNEL. The results showed that: (1) PPAR-γ expressedon two lung cancer cell lines; (2) PPAR-γ activated by ligands could inhibit human lung cancer cellgrowth remarkably; (3) PPAR-γ agonists could induce apoptosis to inhibit lung cancer cell growth.It was concluded that PPAR-γ expressed in lung cancer cell can be activated by ligands and can inhib-it lung cancer cell growth through induction of apoptosis.