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目的:探讨“芪香”气雾剂对流感病毒肺炎小鼠肺部炎性损伤的影响及机制。方法:以流感病毒亚甲型鼠肺适应株A/PR/8/34(H1N1)感染小鼠为模型,用常规HE染色法观察“芪香”气雾剂对肺部炎性损伤的影响;采用ELISA法观察血清IFN-γ、IL-10含量。结果:“芪香”气雾剂预防给药后,与模型组比较,肺部病变明显减轻,有效控制炎症反应的程度和范围,阻止病灶的蔓延,显著减轻小鼠肺部炎性损害;提高血清IFN-γ、IL-10含量。结论 “:芪香”气雾剂可减少流感引起的肺部炎性损伤,其机制可能与调节促炎因子IFN-γ与抗炎因子IL-10相对平衡的状态有关。
Objective: To investigate the effect of “Qiqi” aerosol on inflammatory injury of lung in mice with influenza virus pneumonia and its mechanism. Methods: The mouse model of influenza A virus-infected lung-adapted lung strain A / PR / 8/34 (H1N1) was used as the model, and the effect of “Qixiang” aerosol on inflammatory injury The serum contents of IFN-γ and IL-10 were measured by ELISA. Results: Compared with the model group, the “Qiqi” aerosol preventive administration significantly reduced lung lesions and effectively controlled the degree and extent of inflammatory reactions, prevented the spread of the lesions and significantly reduced the lung inflammatory damage in mice ; Increase serum IFN-γ, IL-10 content. Conclusion: Qiqi aerosol can reduce lung inflammation caused by influenza-induced injury, the mechanism may be related to the regulation of pro-inflammatory cytokine IFN-γ and anti-inflammatory cytokine IL-10 relative balance of the state.