【摘 要】
：
Levodopa (L-DOPA),a precursor of dopamine,is commonly prescribed for the treatment of the Parkinson\'s disease (PD).However,oral administration of levodopa results in a high level of homocysteine in the peripheral circulation,thereby elevating the risk
【机 构】
：
School of Materials Science and Engineering,Key Laboratory for Polymeric Composite and Functional Ma
论文部分内容阅读
Levodopa (L-DOPA),a precursor of dopamine,is commonly prescribed for the treatment of the Parkinson\'s disease (PD).However,oral administration of levodopa results in a high level of homocysteine in the peripheral circulation,thereby elevating the risk of cardiovascular disease,and limiting its clinical application.Here,we report a non-invasive method to deliver levodopa to the brain by delivering L-DOPA-Ioaded sub-50 nm nanoparticles via brain-lymphatic vasculature.The hydrophilic L-DOPA was successfully encapsulated into nanoparticles of tannic acid (TA)/polyvinyl alcohol (PVA) via hydrogen bonding using the flash nanocomplexation(FNC) process,resulting in a high L-DOPA-Ioading capacity and uniform size in a scalable manner.Pharmacodynamics analysis in a PD rat model demonstrated that the levels of dopamine and tyrosine hydroxylase,which indicate the dopaminergic neuron functions,were increased by 2-and 4-fold,respectively.Movement disorders and cerebral oxidative stress of the rats were significantly improved.This formulation exhibited a high degree of biocompatibility as evidenced by lack of induced inflammation or other pathological changes in major organs.This antioxidative and drug-delivery platform administered through the brain-lymphatic vasculature shows promise for clinical treatment of the PD.
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