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目的: 探讨肌钙蛋白I(cTnI)对肺炎合并心力衰竭(简称心衰)的临床诊断价值.方法: 抽取我院收治的肺炎合并心衰、单纯肺炎及同期健康体检儿童(对照组)各50例,比较各组血浆cTnI、血浆氨基N末端B型钠尿肽前体(NT-proBNP)及心功能指标,通过直线相关分析法分析血浆cTnI、NT-proBNP与心功能指标的关系,并比较不同心功能分级患儿血浆cTnI、NT-proBNP含量.结果: 3组血浆cTnI、NT-proBNP、左室射血分数(LVEF)、左心室短轴缩短率(LVFS)比较差异均有统计学意义(P<0.05);合并心衰组cTnI和NT-proBNP浓度明显高于单纯肺炎组(P<0.05);不同心功能分级患儿血浆cTnI、NT-proBNP含量比较差异有统计学意义(P<0.05);直线相关分析法显示,肺炎合并心衰患儿血浆cTnI、NT-proBNP含量分别与LVEF、LVFS呈负相关(r分别为-0.702、-0.638和-0.826、-0.869,P<0.05).结论: cTnI、NT-proBNP含量与心功能指标密切相关,可协助肺炎合并心衰的诊断.“,”Objective: To explore the clinical diagnostic value of cardiac troponin-I(cTnI) and NT-proBNP in children with pneumonia complicated with heart failure(HF).Methods: Fifty children with pneumonia complicated with HF(group A), 50 children with pneumonia and without HF(group B) and 50 healthy children (control group) were enrolled in the study.The plasma cTnI, plasma amino N terminal type B natriuretic peptide precursor(NT-proBNP) and cardiac function indexes were compared among three groups.The relationship between plasma cTnI, NT-proBNP and cardiac function indexes was analyzed by linear correlation analysis, and the levels of plasma cTnI and NT-proBNP in children with different cardiac function grades were compared.Results:There were significant differences in plasma cTnI, NT-proBNP, left ventricular ejection fraction(LVEF) and left ventricular fractional shortening(LVFS) among three groups (P<0.05), and there were significant differences in the levels of plasma cTnI and NT-proBNP levels between children with different cardiac function grades(P<0.05).Linear correlation analysis showed that in children with pneumonia complicated with HF plasma, NT-proBNP and cTnI were negatively correlated with LVEF and LVFS(r=-0.702,-0.638,-0.826,-0.869,P<0.05).Conclusion: cTnI and NT-proBNP are of important significance in the diagnosis of pneumonia with HF, and the levels are significantly related to the cardiac function indexes.