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为研究父母亲高同型半胱胺酸血症 (Hhe)与子女先天性心脏病(CHD)的相关性 ,选择33例正常儿童父母亲和49例CHD患儿父母亲 ,应用高压液相色谱检测血浆同型半胱氨酸 (HCY)。结果显示 ,如以15μmol/L为正常上限 ,CHD母亲组发生Hhe11/32例 (34.38 % ) ,对照组未见异常 ,χ2检验差异有高度显著性(P=0.0014) ;CHD父亲组发生Hhe9/17例(52.94%) ,对照组仅1例 ,差异有显著性(P=0.04)。病例组中有CHD家族史的父母亲发生Hhe者占83.3 %(5/6例) ,高于无CHD家族史的Hhe发生率36.9 %(15/43例) ,P=0.035。结果表明 ,父母亲Hhe与子女CHD有相关性 ,Hhe可能是子女发生CHD的病因之一 ;具有CHD家族史的父母亲更易发生Hhe。
In order to study the correlation between homophilic homocysteinemia (Hhe) and congenital heart disease (CHD) in children, 33 normal children and 49 CHD children were selected for the study. High pressure liquid chromatography Plasma homocysteine (HCY). The results showed that Hhe11 / 32 (34.38%) occurred in the CHD mother group and no significant abnormality in the CHD mother group (P = 0.0014) when the upper limit of normal was 15 μmol / L; Hhe9 / 17 cases (52.94%), the control group only 1 case, the difference was significant (P = 0.04). In the case group, Hhe accounted for 83.3% (5/6) of the parents with CHD family history, 36.9% (15/43 cases) of Hhe with no CHD family history, P = 0.035. The results showed that the parent Hhe and CHD children have a correlation, Hhe may be one of the causes of CHD in children; family history of CHD more likely to occur Hhe.