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目的探讨应用小剂量雌激素治疗围绝经期综合征的临床疗效。方法选择妇产科门诊2012年1月至2013年3月确诊的围绝经期综合征患者92例,随机分为对照组及治疗组,每组46例,对照组给予对症治疗,治疗组患者在对症治疗的基础上给予小剂量雌激素治疗,比较两组患者临床疗效及体内雌激素水平变化。结果治疗组有效率为81.0%,稍高于对照组的有效率(76.1%)但差异无统计学意义(P>0.05)。两组治疗后静脉血FSH与E2水平与治疗前比较差异均有统计学意义(P均<0.05)。治疗前两组静脉血FSH与E2水平比较无统计学差异(P>0.05),治疗后治疗组FSH水平低于对照组,E2水平高于对照组(P均<0.01)。结论小剂量雌激素治疗围绝经期综合征能够有效缓解症状,改善体内雌激素缺乏状态,改善患者的临床治疗效果。
Objective To investigate the clinical efficacy of low-dose estrogen in the treatment of perimenopausal syndrome. Methods Forty-two patients with perimenopausal syndrome diagnosed in obstetrics and gynecology clinic from January 2012 to March 2013 were randomly divided into control group and treatment group, with 46 cases in each group. The patients in control group were given symptomatic treatment. The patients in treatment group were On the basis of symptomatic treatment given low-dose estrogen therapy, clinical efficacy and estrogen levels in both groups were compared. Results The effective rate of the treatment group was 81.0%, slightly higher than that of the control group (76.1%), but the difference was not statistically significant (P> 0.05). The levels of FSH and E2 in venous blood after treatment in both groups were significantly different from those before treatment (all P <0.05). There was no significant difference in FSH and E2 levels between the two groups before treatment (P> 0.05). After treatment, FSH level in treatment group was lower than that in control group, and E2 level was higher than that in control group (all P <0.01). Conclusion Low-dose estrogen treatment of perimenopausal syndrome can effectively relieve symptoms, improve estrogen deficiency in vivo, and improve the clinical effect of the patients.