1982年Goldstein等首次将小囊性附属器癌,即一种缓慢的、局部侵袭性生长的皮肤附属器肿瘤作为一种独立疾病进行了描述。组织学特征为在致密的纤维性间质中有狭长的基底细胞样细胞带,粗看就象汗腺腺瘤,不同的是小囊性附属器癌往往累及皮下及其下方组织。早期不明显的临床表现及轻微的细胞异型性是误诊的原因,并导致治疗不彻底和广泛复发。 In 1982, Goldstein et al. for the first time described the adenocarcinoma of the small cystic adenocarcinoma, a slow, locally invasive, cutaneous adnexal tumor as an independent disease. Histologically, there are narrow basal cell-like cell bands in the dense fibrous stroma, and sweat gland adenomas in the thicker one. The difference is that the small cystic adnexal cancer often involves the subcutaneous tissue and the underlying tissue. Early inconspicuous clinical manifestations and minor cell atypicalities are the causes of misdiagnosis and result in incomplete treatment and extensive relapse.