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乙型肝炎病毒(hepatitis B virus,HBV)与宿主肝细胞存在复杂的相互作用并与病毒复制及相关慢性肝病、肝硬化、肝癌的发生发展有关。microRNA(miRNA)-122是肝脏含量最多的特异性miRNA,大量研究揭示了其在肝细胞脂质代谢、增殖、生物钟调节及丙型肝炎病毒感染过程中的重要性。近几年的研究发现肝细胞miRNA-122与HBV复制及HBV的致病机制存在密切关联,并与乙肝肝硬化及肝癌的发生及预后相关,基于miRNA-122的诊断及治疗方法的探索也取得了一定的进展。本文综述了miRNA-122与乙型肝炎病毒复制及相关疾病进展的研究现状。
Hepatitis B virus (HBV) has complex interactions with host hepatocytes and is associated with viral replication and the development of chronic liver disease, cirrhosis, and hepatocellular carcinoma. MicroRNA (miRNA) -122 is the most abundant specific miRNA in the liver. A large number of studies have revealed its importance in lipid metabolism, proliferation, circadian clock regulation and hepatitis C virus infection in hepatocytes. In recent years, the study found that miRNA-122 in hepatocytes is closely related to HBV replication and the pathogenesis of HBV, and is associated with the occurrence and prognosis of hepatitis B cirrhosis and hepatocellular carcinoma. The discovery of miRNA-122 based on the diagnosis and treatment of miRNA-122 A certain progress. This article reviews the progress of miRNA-122 and hepatitis B virus replication and related diseases.