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近年来,妊娠早期测定胎儿性别,特别对血友病和Duchenne肌营养不良症等性连锁疾病,具有非常重要的意义。根据1976年Clements等和1977年Belisle等提出女性胎儿羊水中促卵泡成熟激素(FSH)比男性胎儿显著高的报导,作者对这一重要发现进行了进一步研究,对101例妊娠期为11～22周的受检者的羊水做了测定,其中48例男性胎儿,53例女性胎儿。抽出的羊水标本储存于-20℃,使用抗-FSH血清进行荧光免疫试验,测定FSH浓度。妊娠11～13周时男女胎儿羊水中FSH浓度没有差异,男性胎儿13例中有12例,女性胎儿12例中有9例,FSH值<5μg/l,无1例高于23μg/l。妊娠
In recent years, the fetus sex determination in early pregnancy, especially for Hemophilia and Duchenne muscular dystrophy and other sex-linked diseases, is of great significance. According to Clements et al., 1976 and Belisle et al., 1977, the authors report that this important finding was further investigated in women with fetal ovarian follicle-stimulating hormone (FSH) that is significantly higher than in male fetuses. 101 pregnant women with gestational age ranging from 11 to 22 Amniotic fluid tests were performed on week subjects, including 48 male fetuses and 53 female fetuses. The extracted amniotic fluid specimens were stored at -20 ° C and anti-FSH serum was used for fluorescence immunoassay to determine the concentration of FSH. There was no difference in the FSH concentrations in amniotic fluid between male and female fetuses at 11-13 weeks of gestation. There were 12 of 13 males and 9 of 12 females with FSH values <5 μg / l, none of which were higher than 23 μg / l. Pregnancy