肿瘤坏死因子 α(TNF α)通过多种机制参与卵巢癌的生物学变化 ,TNF α及其受体分泌量的变化可能与卵巢癌进展有关。近年来采用其治疗卵巢癌 ,主要集中在利用TNF α与多种化疗药物产生协同的细胞毒作用以及促使内源性TNF α的产生来杀伤癌细胞。TNF α重组蛋白疗法、基因疗法和TNF α单克隆抗体疗法为卵巢癌的治疗带来希望 Tumor necrosis factor alpha (TNFα) is involved in the biological changes of ovarian cancer through a variety of mechanisms. The changes of TNFα and its receptor secretion may be related to the progression of ovarian cancer. In recent years, its treatment of ovarian cancer, mainly focused on the use of TNFα and a variety of chemotherapeutic drugs to produce a synergistic cytotoxic effect and to promote the production of endogenous TNFα to kill cancer cells. TNFα Recombinant Protein Therapy, Gene Therapy, and TNFα Monoclonal Antibody Therapy Offer Hopes for the Treatment of Ovarian Cancer