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目的验证α受体阻滞剂乌拉地尔对急重症高血压的降压效果及不良反应。方法采用静脉先推后滴方法,同时定时测定患者的收缩压、舒张压及心率变化,并监测心电图、血常规、尿常规、血脂、血糖、血清谷丙转氨酶及尿素氮变化。结果入组48例患者,用药5分钟起效,30分钟内血压变化明显,平均收缩压下降33.8mmHg,平均舒张压下降13.6mmHg。用药前后心率无明显变化。用药前后血尿常规无变化,肝肾功血糖血脂无异常变化。结论α受体阻滞剂乌拉地尔对急重症高血压是一安全、速效的降压制剂,疗效确切,无反射性心率加快,未发现对肝肾功能的损害,不良反应小。
Objective To verify the antihypertensive effects and adverse reactions of α-blocker urapidil in patients with acute and severe hypertension. Methods The method of intravenous first push and after drip was used. At the same time, the changes of systolic blood pressure, diastolic blood pressure and heart rate were measured regularly. The changes of electrocardiogram, blood routine, urine routine, blood lipid, blood glucose, serum alanine aminotransferase and urea nitrogen were monitored. Results The 48 patients enrolled in this study started the treatment with 5 minutes of medication. The changes of blood pressure were obvious in 30 minutes. The average systolic blood pressure decreased by 33.8 mmHg and the average diastolic blood pressure decreased by 13.6 mmHg. No significant changes in heart rate before and after treatment. No change in hematuria before and after treatment, no abnormal changes in liver and kidney function blood sugar and blood lipids. Conclusion The α blocker of urapidil is a safe and effective antihypertensive preparation for acute and severe hypertension. The curative effect is definite, and the reflexive heart rate is accelerated. No damage to liver and kidney functions is found, and adverse reactions are small.