论文部分内容阅读
目的探讨中国广东人群多酚类化合物摄入与结直肠癌发病的关系。方法采用病例对照研究设计,共纳入1802例结直肠癌病例和1856例对照,病例组与对照组按照年龄(±5岁)和性别进行频数匹配。采用经过效度和信度评估的食物频数问卷,面对面询问研究对象膳食摄入情况,收集一般人口学和生活方式等资料。将能量调整后的多酚类化合物摄入情况依据其在对照组中的分布按四分位法分组,以最低四分位组做参照,采用非条件Logistic回归模型,在调整了潜在的混杂因素后,分析多酚类化合物摄入与结直肠癌发病的关系。结果总的多酚类化合物摄入与结直肠癌发病无关,校正潜在的混杂因素后,与摄入最低组(Q1)相比,总的多酚类化合物摄入最高组(Q4)的OR(95%CI)为0.94(95%CI=0.76~1.15)。酚酸、芪类化合物及其他多酚类化合物的摄入与结直肠癌发病呈负相关,与摄入最低组相比,最高组的OR(95%CI)分别为0.78(0.64~0.96)、0.53(0.43~0.66)和0.70(0.56~0.86),趋势性检验均有统计学意义(P<0.05)。而黄酮类化合物、木酚素摄入与结直肠癌的发病无关。结论酚酸、芪类及其他多酚类化合物与结直肠癌发病呈负相关。本研究未显示黄酮类化合物、木酚素及总的多酚类化合物与结直肠癌之间的作用。
Objective To investigate the relationship between the intake of polyphenols and the incidence of colorectal cancer in Guangdong province of China. Methods A case-control study was designed. A total of 1802 cases of colorectal cancer and 1856 controls were enrolled in this study. The frequency of patients was matched according to age (± 5 years) and gender. Using the questionnaire of food frequency assessed by validity and reliability, face-to-face interrogation of dietary intake of the subjects, general demography and lifestyle information were collected. The intake of energy-adjusted polyphenolic compounds was grouped by quartiles according to their distribution in the control group, with the lowest quartile as the reference and a non-conditional logistic regression model, adjusted for potential confounding factors After analyzing the relationship between the intake of polyphenols and the incidence of colorectal cancer. Results Total polyphenolic uptake was not associated with colorectal cancer onset. After correcting for potential confounding factors, total polyphenols uptake in the highest group (Q4) compared to the lowest (Q1) intake (OR 95% CI) was 0.94 (95% CI = 0.76-1.15). The intake of phenolic acids, stilbene compounds and other polyphenolic compounds was negatively correlated with the incidence of colorectal cancer. Compared with the lowest intake group, the highest (95% CI) of the highest group was 0.78 (0.64-0.96) 0.53 (0.43-0.66) and 0.70 (0.56-0.86) respectively. The trend test was statistically significant (P <0.05). The flavonoids, lignan intake and colorectal cancer incidence has nothing to do. Conclusion Phenolic acids, stilbenes and other polyphenols are negatively correlated with the incidence of colorectal cancer. This study does not show the role of flavonoids, lignans and total polyphenols in colorectal cancer.