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目的探讨影响口周皮炎发病的危险因素,为制定治疗和预防方案提供依据。方法对入选的120例口周皮炎患者及同期110例非口周皮炎患者进行问卷调查及实验室检查,并对相关因素进行单因素分析及多因素Logistic回归分析。结果单因素分析显示,年龄、咽拭子真菌涂片、系统性疾病、发病前用药史、女性口服避孕药及妊娠在两组间差异无统计学意义(P>0.05),将筛选出的有统计学意义的变量进行多因素Logistic回归分析,结果显示女性、幽门螺杆菌感染、鼻炎或鼻窦炎、进食过热食物和辛辣刺激食物的饮食习惯、日晒、精神因素、劳累和过敏性疾病史为口周皮炎发病的致病危险因素(P<0.05)。结论积极治疗幽门螺杆菌感染、鼻炎、鼻窦炎,减少日晒,形成良好的饮食习惯、放松心情、避免过度劳累对于口周皮炎的治疗和预防具有一定作用。
Objective To explore the risk factors that affect the pathogenesis of perioral dermatitis and provide evidence for the development of treatment and prevention programs. Methods A total of 120 patients with perioral dermatitis and 110 patients with non-periventricular dermatitis were enrolled in the questionnaire and laboratory tests. Univariate analysis and multivariate Logistic regression analysis were used to analyze the related factors. Results Univariate analysis showed that age, pharyngeal swab fungal smear, systemic diseases, pre-morbid medication history, female oral contraceptives and pregnancy had no significant difference between the two groups (P> 0.05) Statistical Logistic regression analysis of variables with statistical significance showed that the history of female, Helicobacter pylori, rhinitis or sinusitis, eating habits of overheated food and spicy food, sun exposure, psychiatric factors, tiredness and allergic diseases were The incidence of peri-oral dermatitis risk factors (P <0.05). Conclusion Active treatment of Helicobacter pylori infection, rhinitis, sinusitis, reduce the sun, the formation of a good diet, relax and avoid over-exertion for the treatment and prevention of perioral dermatitis have a role.