杂交-杂交瘤是把分泌不同特异性抗体的细胞进行融合而产生的,它能分泌同时表现两个亲代细胞Ig结合特异性的杂交分子,这种具有两个不同特异性的分子嵌合体就是双特异性单克隆抗体(杂交-杂交单克隆抗体)。作者运用杂交-杂交瘤技术成功地制备出一种能同时识别两种不同抗原的双特异性单克隆抗体,这种命名为28.9.8的单抗既能识别肿 Hybridization - Hybridomas are produced by the fusion of cells that secrete antibodies of different specificities. They can secrete hybridized molecules that exhibit the Ig-binding specificity of both parental cells. The two molecular chimeras with different specificities are bis Specific monoclonal antibodies (hybrid-hybrid monoclonal antibodies). The authors used hybridization-hybridoma technology to successfully create a bispecific monoclonal antibody that recognizes two different antigens simultaneously. The monoclonal antibody, designated 28.9.8, recognizes both swollen