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目的:探讨极低出生体重儿发生支气管肺发育不良(Bronchopulmonary Dysplasia,BPD)的临床高危因素。方法:回顾性分析NICU收治的极低出生体重儿199例患儿的临床资料,根据是否发生BPD分为BPD组和非BPD组,分析BPD发生的可能危险因素。结果:199例低出生体重儿中有48例发生BPD,发病率为24.1%。与非BPD患儿组相比,BPD组患儿在机械通气时间、总吸氧时间、吸氧浓度>40%时间、宫内感染、合并动脉导管未闭、院内感染等方面比较差异有统计学意义(P<0.05),Logistic回归分析结果显示机械通气时间、宫内感染、吸氧浓度>40%时间为疾病发生的危险因素。结论:预防宫内感染可降低BPD的发生率,长时间机械通气及高浓度吸氧为BPD发生的高危因素。
Objective: To investigate the clinical risk factors of bronchopulmonary dysplasia (BPD) in very low birth weight infants. Methods: The clinical data of 199 children with very low birth weight (NICD) admitted to NICU were retrospectively analyzed. The possible risk factors for BPD were analyzed according to whether BPD was divided into BPD group and non-BPD group. Results: Of the 199 cases of low birth weight infants, 48 cases developed BPD, the incidence was 24.1%. BPD group compared with non-BPD children in mechanical ventilation time, total oxygen inhalation time, oxygen concentration> 40% of time, intrauterine infection, patent ductus arteriosus, nosocomial infections and other aspects of statistical differences (P <0.05). Logistic regression analysis showed that the time of mechanical ventilation, intrauterine infection and oxygen concentration> 40% were the risk factors for the disease. Conclusion: Prevention of intrauterine infection can reduce the incidence of BPD, prolonged mechanical ventilation and high concentrations of oxygen for the risk factors for BPD.