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目的 研究 BCL - 2蛋白、p5 3蛋白表达与胆管癌预后的关系。 方法 应用免疫组化研究 40例胆管癌组织中 BCL - 2蛋白、p5 3蛋白表达及其与胆管癌组织类型及术后生存期的关系。 结果 胆管癌组织中 BCL - 2蛋白和 p5 3蛋白表达阳性率分别为 5 5 %和 47.5 % ;BCL - 2蛋白与 p5 3蛋白的表达呈负相关 ,低分化癌 p5 3蛋白阳性率高于高分化癌 ,高分化癌 BCL - 2蛋白阳性率高于低分化癌 ( P<0 .0 1) ;BCL - 2蛋白表达高或 p5 3蛋白表达低 ,其患者的术后生存期较长 ;反之 ,术后生存期较短 ( P<0 .0 1)。 结论 BCL - 2蛋白及 p5 3蛋白的表达情况可作为胆管癌预后判断的参考指标。
Objective To study the relationship between the expression of BCL-2 protein and p53 protein and the prognosis of cholangiocarcinoma. Methods The expression of BCL-2 protein and p53 protein in 40 cases of cholangiocarcinoma were studied by immunohistochemistry. Results The positive rates of BCL-2 protein and p53 protein in cholangiocarcinoma were 55% and 47.5% respectively. The expression of BCL-2 and p53 protein was negatively correlated. The positive rate of p53 protein in poorly differentiated cancer was higher than The positive rate of BCL-2 protein in well-differentiated and well-differentiated carcinomas was higher than that in poorly-differentiated carcinomas (P < 0.01); the expression of BCL-2 protein was high or the expression of p53 protein was low, and the survival time of patients was longer; The postoperative survival time was shorter (P < 0.01). Conclusion The expression of BCL-2 protein and p53 protein can be used as a reference index for the prognosis of cholangiocarcinoma.