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目前不少医院配制的环胞苷滴眼剂均以生理盐水为溶媒,用无菌操作法配成。曾有报道,用不同pH值的磷酸盐缓冲液配制的环胞苷滴眼剂,对热不稳定,100℃消毒30min,含量下降到80%以下。室温放置pH值6.0左右的有效期约40天,pH值7.0左右的有效期约15天,且pH值随放置时间的延长而下降。用生理盐水配制的环胞苷滴眼剂的稳定性未见报道,为此,我们做了实验性考察。
At present, many hospitals have formulated cytidine eye drops with saline as the vehicle, using aseptic technique. It has been reported that with different pH values of phosphate buffer formulated cytidine eye drops, heat instability, 100 ℃ disinfection 30min, the content dropped to below 80%. The pH value of about 6.0 at room temperature for about 40 days, the pH value of about 7.0 effective period of about 15 days, and the pH value with the extension of time and decreased. Cyclophosphamide eye drops formulated with saline stability has not been reported, for which we did an experimental study.