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运用脑组织原位杂交法，观察戊四唑点燃癫痫模型脑组织中ＳＳｍ ＲＮＡ 的表达及草果知母汤作用后的变化。结果：与正常对照组相比，模型组脑皮层ＳＳｍ ＲＮＡ 的含量明显升高（ Ｐ＜０－０１） ，海马中ＳＳｍ ＲＮＡ 的含量明显降低（ Ｐ＜ ０－００１） ；与模型组相比，西药组（ 苯巴比妥） 及中药组（ 草果知母汤） 皮层ＳＳｍ ＲＮＡ 含量明显降低（ Ｐ＜ ０－０５） 。降低皮层组织ＳＳｍ ＲＮＡ 的含量，可能是草果知母汤抗癫痫的作用途径之一。
The brain tissue in situ hybridization was used to observe the expression of SSm RNA in brain tissue of pentylenetetrazole-kindled epilepsy model and the changes of Zhimuzhimu decoction. Results: Compared with the normal control group, the SSm RNA content in the cortex of the model group increased significantly (P<0-01), and the SSm RNA content in the hippocampus decreased significantly (P<0-001); compared with the model group, Western medicine group (phenobarbital) and traditional Chinese medicine group (Xianguo Zhimu Decoction) cortex SSm RNA content was significantly reduced (P < 0-05). Decreasing the content of SSm RNA in cortical tissue may be one of the ways of anti-epilepsy effect of Zhimu Tang.