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目的:分析我院2012年276例药品不良反应的发生特点,为临床合理用药提供参考。方法:利用Excel 2003软件对ADR病例的年龄、性别,引发ADR的药品类别、给药途径、药物剂型,ADR累及器官或系统及临床表现,报告人员职业等进行统计分析。结果:276例ADR报告中,男125例(45.3%),女151例(54.7%);以静脉滴注方式给药的ADR比例较高,为193例(69.93%);以注射剂出现的ADR为多,167例(60.51%);所涉及的药品中抗菌药引起的ADR比例较高,65例(23.55%);引起ADR的药品前10位中有9个为抗菌药;严重的ADR共3例(1.09%);ADR临床表现以皮肤及其附件损害为主,55例(18.71%),其次为全身性损害,35例(11.90%);填报ADR报告的以药师为主(61.23%),其次为护士(32.61%),医生较少(6.16%)。结论:应加强ADR的监测并重视在ADR报告中发现的用药问题,并及时向临床反馈,促进临床合理用药。
Objective: To analyze the characteristics of adverse drug reaction in 276 cases in our hospital in 2012, and provide references for clinical rational drug use. Methods: Excel 2003 software was used to analyze the age, sex, drug category, route of administration, drug dosage form, organ involved in ADR, systemic and clinical manifestations, occupational status, etc of ADR patients. RESULTS: Among 276 ADR cases, 125 (45.3%) were male and 151 (54.7%) were female. The proportion of ADR administered intravenously was 193 cases (69.93%). The incidence of ADR (60.51%). Among the drugs involved, the proportion of ADR caused by antimicrobial agents was high in 65 cases (23.55%). Nine of the top 10 drugs causing ADR were antimicrobial agents. The patients with severe ADR 3 cases (1.09%). The clinical manifestations of ADR were mainly skin and its accessory lesions, 55 cases (18.71%) followed by systemic injury, 35 cases (11.90%); ), Followed by nurses (32.61%), fewer doctors (6.16%). Conclusion: The monitoring of ADR should be strengthened and the medication problems found in the ADR report should be emphasized, and timely feedback to the clinic should be made to promote clinical rational drug use.