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目的:观察感染血吸虫尾蚴后早期用蒿甲醚(Art)或吡喹酮(Pra)治疗,对宿主肝组织的影响。方法:犬感染198-202条尾蚴后d7ig Art 10 mg·kg~(-1),Art胶囊(ArtC)15mg·kg~(-1)或感染后d 21ig Pra 30-40 mg·kg~(-1),1—2 wk重复给药1次,共2—4次;兔每隔日感染48—52条尾蚴,共5次,并于第1次感染后d7或d 21 ig上述剂量的Art和Pra,停药后4—5wk剖杀取肝作切片观察。结果:犬与兔经Art或Pra早期治疗后,减♀虫率达92.1％—100％,肝切片中的总虫卵肉芽肿数分别减少70.9％—97.3％和76.5％—97.4％,肝叶结构和肝索排列正常。结论:2种药物早期治疗对宿主肝脏有保护作用。
Objective: To observe the effect of artemether (Art) or praziquantel (Pra) on the host liver tissue in the early stage of Schistosoma japonicum infection. Methods: After treatment with 198-202 cercariae, the d7ig Art 10 mg · kg -1, Art capsule 15 mg · kg -1 or d 21ig Pra 30-40 mg · kg - 1), 1-2 wk repeated administration 1, a total of 2-4 times; rabbits infected 48-52 cercariae every other day for a total of 5 times, and after the first infection d7 or d 21 ig the above dose Art and Pra, cut 4-5wk after drug withdrawal for liver slices for observation. Results: After treatment with Art or Pra, dogs and rabbits reduced the rate of echinococcosis by 92.1% -100% and total number of granulomas in liver slices by 70.9% -97.3% and 76.5% -97.4% Structure and liver were normal. Conclusion: Early treatment of two drugs has protective effect on the host liver.