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有人认为总状升麻Cimicifuga racemosa(CR)提取物抑制人乳腺癌细胞MCF-7的增殖是由于其抗雌激素作用,然而CR中成分与所有已知的雌激素受体没有结合作用,因此其抗肿瘤机理与这些受体无关。环境污染毒物中的多环芳香烃类化合物可通过激活芳基烃类受体(AhR)直接产生抗雌激素作用。有研究表明许多植物提取物(包括CR)具有
It has been suggested that the extract of Cimicifuga racemosa (CR) in the form of Cimicifuga racemosa (CR) inhibits the proliferation of human breast cancer cell MCF-7 due to its anti-estrogen action, whereas the component of CR does not bind to all known estrogen receptors, and therefore The anti-tumor mechanism has nothing to do with these receptors. Polycyclic aromatic hydrocarbon compounds in environmental pollutants can directly produce anti-estrogen effects through the activation of aryl hydrocarbon receptors (AhR). Studies have shown that many plant extracts (including CR) have