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作者对1958年10月至1992年10月手术治疗并经病理证实的70例妊娠期及哺乳期乳腺癌患者的临床资料进行回顾性分析,以探讨影响预后的主要因素。结果显示:妊娠期及哺乳期乳腺癌患者治疗后5年生存率与肿瘤分期、治疗时妊娠和哺乳时间、病程、手术方式、病理类型、肿瘤分化程度、有无肿瘤复发转移和雌激素受体状况均有明显关系(P<0.05),与患者年龄和是否终止妊娠无明显关系(P>0.05)。妊娠期及哺乳期乳腺癌患者的预后比普通乳腺癌差,二者5年生存率分别为55.7%和74.3%,但在相同分期和年龄的患者,其生存率无明显差别。因此,对妊娠期及哺乳期乳腺癌应提高早期诊断率,一旦确诊应积极采取以根治性手术为主的综合治疗,不仅缩短疗程,还能提高生存率;终止妊娠不能改善患者预后而不应常规进行;治疗后近期再次妊娠可能影响预后
The authors retrospectively analyzed the clinical data of 70 cases of breast cancer during pregnancy and breast cancer that were surgically treated from October 1958 to October 1992 and confirmed by pathology to explore the main factors affecting the prognosis. The results showed that 5-year survival rate and tumor stage, duration of pregnancy and breast-feeding during treatment, course of disease, surgical method, pathological type, degree of tumor differentiation, presence or absence of tumor recurrence, and estrogen receptor in breast cancer patients during pregnancy and lactation There was a significant relationship between the conditions (P < 0.05), and no significant relationship with the patient’s age and whether the termination of pregnancy (P> 0.05). The prognosis of breast cancer patients during pregnancy and lactation is worse than that of ordinary breast cancer. The 5-year survival rates of the two are 55.7% and 74.3%, respectively. However, there is no significant difference in the survival rate between patients with the same stage and age. Therefore, for breast cancer during pregnancy and lactation should improve the early diagnosis rate, once diagnosed should be actively taken to radical surgery-based comprehensive treatment, not only shorten the course of treatment, but also improve the survival rate; termination of pregnancy can not improve the prognosis of patients should not Routinely performed; recent pregnancy after treatment may affect the prognosis