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目的 观察肿瘤患者血清TNF α的变化及临床意义。方法 应用放射免疫测定法对 2 0例健康对照者和 70例肿瘤患者进行了血清TNF α含量测定。结果 对照组血清TNF α的含量较低 ,肿瘤患者明显升高(P <0 0 1) ;肿瘤转移和 /或复发时无进一步上升 ,而肿瘤合并胸腹水和恶液质时TNF α上升明显。结论 肿瘤患者血清TNF α水平明显高于对照组 ,随着肿瘤的局部控制及消退 ,体内TNF α含量呈下降趋势 ,因此TNF α含量的变化对肿瘤患者病情变化及预后的判定 ,具有一定的参考价值
Objective To observe the changes and clinical significance of serum TNF α in tumor patients. Methods Radioimmunoassay was used to detect serum TNFα in 20 healthy controls and 70 cancer patients. Results The level of serum TNFα in the control group was lower, and the tumor patients were significantly elevated (P < 0 01). There was no further increase in tumor metastasis and/or recurrence. However, TNF α increased significantly in the tumor with pleural effusion and cachexia. Conclusion The level of TNFα in tumor patients was significantly higher than that in the control group. With the local control and regression of tumors, the TNFα content in vivo showed a decreasing trend. Therefore, the change of TNFα content has a certain reference for the determination of disease conditions and prognosis of tumor patients. value