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[目的]观察解毒化肝汤联合干扰素治疗丙型肝炎肝硬化疗效。[方法]使用随机平行对照方法,将126例住院及门诊患者按病志号抽签/就诊顺序号简单随机分为两组。对照组63例保肝、白蛋白、营养支持;干扰素,100万U/次,3次/周。治疗组63例解毒化肝汤(大黄3g,陈皮6g,绞股蓝10g,珍珠草20g,虎杖、白花蛇舌草各30g,郁金12g,白芍、赤芍各10g,三七粉5g,醋鳖甲、薏苡仁各20g,茯苓、泽泻各15g,麦冬10g,枸杞20g,枣皮10g,山药20g),1剂/d,水煎400m L,早晚口服;干扰素治疗同对照组。连续治疗180d为1疗程。观测临床症状、谷草转氨酶、谷丙转氨酶、血清胆红素、凝血酶原活动度、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效34例,有效26例,无效3例,总有效率95.24%;对照组显效30例,有效22例,无效11例,总有效率82.54%;治疗组疗效优于对照组(P<0.05)。肝功能指标两组均有改善(P<0.01),治疗组改善优于对照组(P<0.05)。[结论]解毒化肝汤联合干扰素治疗丙型肝炎肝硬化疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of detoxification liver soup combined with interferon on hepatitis C cirrhosis. [Methods] Using randomized parallel control method, 126 inpatients and outpatients were randomly divided into two groups randomly according to the patient’s lottery number and visiting sequence number. Control group, 63 cases of liver protection, albumin, nutritional support; interferon, 1 million U / time, 3 times / week. Treatment group, 63 cases of detoxification liver soup (Rhubarb 3g, dried tangerine peel 6g, Gynostemma 10g, pearl grass 20g, Polygonum cuspidatum, each 30g Hedyotis diffusa, turmeric 12g, white peony root, red peony 10g, notoginseng powder 5g, vinegar and turtle A, Coix seed 20g, Poria, Alisma each 15g, Ophiopogon japonicus 10g, Chinese wolfberry 20g, jujube skin 10g, yam 20g), 1 / d, decoction 400m L, sooner or later oral; interferon treatment with the control group. Continuous treatment of 180d for a course of treatment. Observed clinical symptoms, aspartate aminotransferase, alanine aminotransferase, serum bilirubin, prothrombin activity, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 34 cases were markedly effective, 26 cases were effective, 3 cases were ineffective, and the total effective rate was 95.24%. In the control group, 30 cases were markedly effective, 22 cases were effective and 11 cases were ineffective. The total effective rate was 82.54% (P <0.05). Liver function indicators improved in both groups (P <0.01), and the treatment group improved better than the control group (P <0.05). [Conclusion] Detoxification Hugan Decoction combined with interferon is effective in treating hepatitis C cirrhosis without serious adverse reactions and is worth promoting.