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临床上长期应用肝素抗凝治疗,可导致骨质疏松和自发性骨折。肝素存在于骨髓肥大细胞的异染色颗粒中,骨质疏松和肾性骨病时肥大细胞数目增加。故推测骨质疏松与肝素有关。肝素用于骨硬化大鼠的治疗可增加破骨细胞数目,骨再建并使骨结构正常化,但确切机制尚不清楚。本研究通过肝素对离体鸡和鼠破骨细胞骨吸收作用的评价对此问题
Long-term clinical application of heparin anticoagulant therapy, can lead to osteoporosis and spontaneous fracture. Heparin is present in heterochromatic granules of myeloid mast cells and increases in the number of mast cells in osteoporosis and renal osteodystrophy. It is speculated that osteoporosis and heparin. Heparin treatment of osteoarthritis in rats can increase the number of osteoclasts, bone remodeling and bone structure normalization, but the exact mechanism is not yet clear. This study evaluated the effect of heparin on bone resorption in isolated chickens and murine osteoclasts against this problem