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Objective To study the role and mechanism of sphingosine-phosphate(S1P)/sphingosine-1-phosphate receptor 1(S1P1)signal pathway during post conditioning of hypertrophic cardiomyocytes.Methods Neonatal rat cardiomyocytes were isolated and cultured,then stimulated by norepinephrine(NE)to induce cardiomyocytes hypertrophy.Using tri-gas incubator to create hypoxia
Objective To study the role and mechanism of sphingosine-phosphate (S1P) / sphingosine-1-phosphate receptor 1 (S1P1) signal pathway during post conditioning of hypertrophic cardiomyocytes. Methods Neonatal rat cardiomyocytes were isolated and cultured, then stimulated by norepinephrine to induce cardiomyocytes hypertrophy. Using tri-gas incubator to create hypoxia