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目的： 测定甲硝唑对头孢噻肟钠蛋白结合率的影响。方法： 采用超滤法结合高效液相色谱法测出游离药物浓度， 比较未加和加入甲硝唑后头孢噻肟钠的蛋白结合率。结果： 头孢噻肟钠的超滤回收率为９９－１％ ， 未加及加入甲硝唑后头孢噻肟钠的蛋白结合率分别为３２－２ ％ 和３０－８％ 。结论： 甲硝唑对头孢噻肟钠的蛋白结合率基本无影响。
Objective: To determine the effect of metronidazole on cefotaxime sodium binding rate. Methods: The concentration of free drug was measured by ultrafiltration combined with high performance liquid chromatography (HPLC). The protein binding rate of cefotaxime sodium after adding metronidazole was compared. Results: The recoveries of cefotaxime sodium were 99-1%. The protein binding rates of cefotaxime sodium after addition of metronidazole were 32-2% and 30-8% respectively. Conclusion: Metronidazole has no effect on the protein binding rate of cefotaxime sodium.