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乙醇和二甲亚砜(DMSO)等有机溶剂常被用于动静脉畸形和颅内动脉瘤的栓塞治疗。在治疗同时作者发现有机溶剂对脑组织和脑血管的影响不可忽视,它取决于溶剂的类型、浓度、总量、内皮暴露时间及注入速度和血流速度等。本文探讨了动脉内灌注不同浓度的乙醇和DMSO对脑血管和脑组织的形态学影响。 Wistar大鼠,重250～300g,腹膜下注射戊巴比妥钠(50mg/kg)麻醉后暴露颈内、外动脉,并将颈外动脉用微型夹夹住。各组(每组6只)分别经颈总动脉输入0.2ml生理盐水、10％、40％或70％乙醇或DMSO(100％)。每次注射时间超过5秒钟。注射5分钟后暴露心脏,并以18号针向左心室注入2％伊文思蓝液
Organic solvents such as ethanol and dimethylsulfoxide (DMSO) are often used in arteriovenous malformations and intracranial aneurysms for embolization. At the same time, the authors found that the influence of organic solvents on brain tissue and cerebrovascular can not be ignored, it depends on the type of solvent, concentration, total amount, the time of exposure to the endothelium and the rate of injection and blood flow velocity. This article explored the morphological effects of intra-arterial infusion of ethanol and DMSO at different concentrations on cerebrovascular and brain tissue. Wistar rats weighing 250-300 g were anesthetized by intraperitoneal injection of sodium pentobarbital (50 mg / kg), the internal and external carotid arteries were exposed, and the external carotid artery was clamped with a micro-clamp. Groups (6 per group) were given either 0.2 ml normal saline, 10%, 40% or 70% ethanol or DMSO (100%) via the common carotid artery. Each injection time more than 5 seconds. After 5 minutes of injection, the heart is exposed and a 2% Evans blue solution is injected into the left ventricle using a 18 gauge needle