Objective To explore the predictors of condom-use self-efficacy in Chinese college students according to the extended parallel process model(EPPM)-based integrated model.Methods A total of 3,081 college students were anonymously surveyed through self-administered questionnaires in Guangzhou and Harbin,China.A structural equation model was applied to assess the integrated model.Results Among the participants,1,387(46.7%)were male,1,586(53.3%)were female,and the average age was 18.6 years.The final integrated model was acceptable.Apart from the direct effect(r=0.23),perceived severity had two indirect effects on condom-use self-efficacy through the attitude to HIV education(r=0.40)and intention to engage in premarital sex(r=-0.16),respectively.However,the perceived susceptibility mediated through the intention to engage in premarital sex(intent-to-premarital-sex)had a poor indirect impact on condom-use self-efficacy(total effect was-0.06).Furthermore,attitude toward HIV health education(r=0.49)and intent-to-premarital-sex(r=-0.31)had a strong direct effect on condom-use self-efficacy.In addition,male students perceived higher susceptibility,stronger intent-to-premarital-sex,and lower condom-use self-efficacy than female students.Conclusion The integrated model may be used to assess the determinants of condom-use self-efficacy among Chinese college students.Future research should focus on raising the severity perception,HIV-risk-reduction motivation,and the premarital abstinence intention among college students.Furthermore,considering the gender differences observed in the present survey,single-sex HIV education is required in school-based HIV/sex intervention. Objective To explore the predictors of condom-use self-efficacy in Chinese college students according to the extended parallel process model (EPPM) -based integrated model. Methods A total of 3,081 college students were anonymously surveyed through self-administered questionnaires in Guangzhou and Harbin , China. A structural equation model was applied to assess the integrated model. Results in the participants, 1,387 (46.7%) were male, 1,586 (53.3%) were female, and the average age was 18.6 years. The final integrated model was acceptable .Apart from the direct effect (r = 0.23) and intention to engage in premarital sex (r = -0.16), perceived severity had two indirect effects on condom-use self-efficacy through the attitude to HIV education respectively. Yet, the perceived susceptibility mediated through the intention to engage in premarital sex (intent-to-premarital-sex) had a poor indirect impact on condom-use self-efficacy (total effect was-0.06) .Furthermore, attitude toward HIV health education ( r = 0.49) and intent-to-premarital-sex (r = -0.31) had a strong direct effect on condom-use self- efficacy. In addition, male students perceived higher susceptibility, stronger intent-to-premarital-sex, and lower condom-use self-efficacy than female students.Conclusion The integrated model may be used to assess the determinants of condom-use self-efficacy among Chinese college students. Future research should focus on raising the severity perception, HIV-risk-reduction motivation , and the premarital abstinence intention among college students. More than, considering the gender differences observed in the present survey, single-sex HIV education is required in school-based HIV / sex intervention.