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使二氯磷酸乙酯(EDP)与自制双端羟基的PCL进行缩聚反应,得到了系列不同组成的磷酸酯-聚己内酯共聚物(PPE-PCL)。1 H-NMR及GPC测试结果显示共聚物中EG与CL的结构单元之比与投料比接近,调节反应配比可将共聚物的分子量控制在3.42×103到8.03×103之间;DSC结果表明,磷酸酯基团的引入使PPE-PCL的结晶度明显低于PCL;PPE-PCL自组装形成的胶束在pH为9.4的水溶液中降解10d后,胶束粒径由800nm减小到450nm,且仍保持较完整的球形结构。
Polycondensation of ethyl dichlorophosphate (EDP) with self-made double-terminated PCL gave a series of phosphate-polycaprolactone copolymers (PPE-PCL) with different compositions. The results of 1 H-NMR and GPC showed that the ratio of EG to CL in the copolymer was close to the feed ratio, and the molecular weight of the copolymer was controlled between 3.42 × 10 3 and 8.03 × 10 3 by adjusting the reaction ratio. , The crystallinity of PPE-PCL was significantly lower than that of PCL by the introduction of phosphate groups. After the micelles formed by self-assembly of PPE-PCL degraded 10 days in pH 9.4 aqueous solution, the micelle size decreased from 800nm to 450nm, And still maintain a more complete spherical structure.