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目的探讨维生素E对心肌缺血／再灌注（I／R）损伤左心功能的影响。方法结扎家兔左冠状动脉前降支造成心肌I／R模型，14只家兔分为治疗组（维生素E50mg·kg－1肌肉注射）及对照组（等量的生理盐水肌肉注射），在结扎冠状动脉前及放松后0．5、1、2、3、4h分别测量左心室收缩末期压（LVESP）、舒张末期压（LVEDP）及平均压，分别以表示，统计学处理采用配对t检验。结果结扎冠状动脉前，治疗组和对照组的LVESP和LVEDP均无明显差异（P＞0．05）。而心肌I／R损伤后，治疗组LVESP显著高于对照组，且以3h及4h升高最为显著（P＜0．05和P＜0．01）。心肌I／R损伤后1～3h，治疗组LVEDP显著低于对照组（P＜0．05和P＜0．01）结论维生素E对心肌I／R损伤后LVESP有升高作用，对LVSDP有降低作用。
Objective To investigate the effect of vitamin E on left ventricular function after myocardial ischemia / reperfusion (I / R) injury. Methods Ligation of left anterior descending coronary artery in rabbits caused myocardial I / R model, 14 rabbits were divided into treatment group (vitamin E50mg · kg-1 intramuscular injection) and control group (equal volume of saline intramuscular injection) Left ventricular end-systolic pressure (LVESP), end-diastolic pressure (LVEDP) and mean pressure were measured before coronary artery and at 0.5, 1, 2, 3 and 4 hours after relaxation respectively. Statistical analysis was performed using paired t-test. Results Before the ligation of the coronary artery, the LVESP and LVEDP of the treatment group and the control group had no significant difference (P> 0.05). After myocardial I / R injury, LVESP in the treatment group was significantly higher than that in the control group (P <0.05 and P <0.01). LVEDP in the treatment group was significantly lower than that in the control group (P <0.05 and P <0.01) 1 ~ 3 h after myocardial I / R injury. Conclusion Vitamin E could increase LVESP after myocardial I / R injury, Reduce the effect.