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目的 定量评价肺癌和肺癌远处转移患者前列环素(PGI2)和血栓素A2(TXA2)水平,为肺癌转移提供诊断、鉴别诊断的依据。方法 采用放射免疫测定技术对原发性肺癌未手术组的6例远处转移,8例肺门转移,7例无转移的患者,肺癌行根治术组的6例出现远处转移,7例出现肺门转移,6例未出现转移的患者进行血浆前列环素和血栓素A2检测。结果 原发性肺癌未手术组和行根治术组,无论是远处转移或肺门转移,其PGI2/TXA2比值均明显低于肺癌无转移患者,P<0.05。但肺癌合并远处转移的患者,PGI2/TXA2比值低于肺癌合并肺门转移的患者,P>0.05。结论 PGI2/TXA2比值对肺癌转移的诊断有重要价值。
Objective To quantitatively evaluate the levels of prostacyclin (PGI2) and thromboxane A2 (TXA2) in patients with lung cancer and distant metastasis of lung cancer, and provide the basis for diagnosis and differential diagnosis of lung cancer metastasis. Methods Radioimmunoassay was used to detect distant metastasis in 6 patients with distant lung metastasis, 8 patients with hilar metastasis, and 7 patients without metastasis in the primary lung cancer group. The distant metastasis occurred in 6 patients with radical lung cancer surgery. Hump metastasis, 6 patients without metastasis, were detected with plasma prostacyclin and thromboxane A2. Results The ratio of PGI2/TXA2 was significantly lower in patients with primary lung cancer without surgery and radical surgery than those without lung cancer, whether distant metastasis or hilar metastasis, P<0.05. However, the ratio of PGI2/TXA2 in lung cancer patients with distant metastasis was lower than that in lung cancer with hilar metastasis (P>0.05). Conclusion The PGI2/TXA2 ratio has important value in the diagnosis of lung cancer metastasis.