以动力性冠状动脉阻塞为主要病因的心绞痛,药物治疗的主要机制是扩张冠状动脉,解除其痉挛。本研究的目的是评价尼可兰迪(Nicorandil),一种新的抗心绞痛药物,解除冠状动脉痉挛的即时效果。 10例冠状动脉痉挛所致的心绞痛患者,男8例女2例,年龄39～61岁。冠状动脉造影8例用Sone氏法,2例用Judking氏法。造影前停用抗心绞痛药物最少12小时,研究过程中连续记录标准12导联心电图。10例中7例发现冠状动脉有固定性狭窄,其中6例为单支病变,1例为双支病变。3例未发现明显病变。观察过程中5例病人有自发性冠状动脉痉挛,即给尼可兰迪4mg静脉注射。另5例用马来酸麦角新碱 Angina pectoris is the main cause of coronary artery obstruction. The main mechanism of medical treatment is to expand the coronary artery and relieve the spasm. The purpose of this study was to evaluate Nicorandil, a new anti-anginal drug that relieves the immediate effects of coronary artery spasms. 10 cases of angina pectoris caused by coronary spasm, 8 males and 2 females, aged 39 to 61 years old. Coronary angiography in 8 cases with Sone’s method, 2 cases with Judking’s method. Anti-angina drugs should be stopped before angiography for a minimum of 12 hours. During the study, standard 12-lead electrocardiograms were recorded continuously. In 10 cases, 7 patients had fixed stenosis of coronary artery, of which 6 were single vessel disease and 1 was double vessel disease. 3 cases did not find obvious lesions. During the observation period, 5 patients had spontaneous coronary spasm, that is, 4 mg intravenous injection of Nicorandil. Another 5 cases with ergometrine maleate