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本文作者在美籍亚洲血统的HBsAg和HBeAg均阳性的孕妇所生新生儿中以重组乙型肝炎疫苗和乙型肝炎免疫球蛋白(HBIG)作母婴传播阻断效果观察,并与血源性乙型肝炎疫苗作比较。 122名新生儿均于出生后24小时内肌肉注射0.5mlHBIG,39人在注射HBIG的同时在另侧注射10μg血源疫苗;83人在注射HBIG2～7天后注射5μg重组疫苗。分别于1和6个月后注射第2、3针,注射剂量仍分别为10μg和5μg。分娩时收集脐带血并采婴儿外周静脉血,以后在1、3、6、9、12和18个月采静脉血。用放射免疫法测定HBsAg、HBeAg、抗(?)
The authors observed the blocking effect of recombinant hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) on maternal-to-infant transmission in neonates born to Asian-born HBsAg and HBeAg-positive pregnant women, Hepatitis B vaccine for comparison. 122 newborns were intramuscularly injected with 0.5 ml of HBIG within 24 hours of birth, 39 were injected with 10 μg of blood-borne vaccine on the other side while HBIG was injected, and 83 were injected with 5 μg of recombinant vaccine 2 to 7 days after HBIG injection. After 1 and 6 months after the injection of the first and second needle, the injection dose were still 10μg and 5μg. Umbilical cord blood was taken during childbirth and peripheral blood was taken from infants, and venous blood was collected at 1, 3, 6, 9, 12 and 18 months later. Determination of HBsAg, HBeAg by radioimmunoassay, anti (?)